See https://www.sqlite.org/compile.html.
DSQLITE_DQS
> This setting disables the double-quoted string literal misfeature.
DSQLITE_DEFAULT_MEMSTATUS
> This setting causes the sqlite3_status() interfaces that track
> memory usage to be disabled.
> This helps the sqlite3_malloc() routines run much faster, and since
> SQLite uses sqlite3_malloc() internally, this helps to make the
> entire library faster.
DSQLITE_OMIT_DEPRECATED
> Omitting deprecated interfaces and features will not help SQLite
> to run any faster.
> It will reduce the library footprint, however. And it is the
> right thing to do.
DSQLITE_OMIT_SHARED_CACHE
> Omitting the possibility of using shared cache allows many
> conditionals in performance-critical sections of the code to be
> eliminated. This can give a noticeable improvement in performance.
Also: https://www.sqlite.org/sharedcache.html
> Shared-cache mode is an obsolete feature.
> The use of shared-cache mode is discouraged.
> Most use cases for shared-cache are better served by WAL mode.
> Applications that build their own copy of SQLite from source code
> are encouraged to use the -DSQLITE_OMIT_SHARED_CACHE compile-time
> option, as the resulting binary will be both smaller and faster.
DSQLITE_OMIT_JSON
Starting with sqlite 3.38.0 the JSON extension became opt-out rather
than opt-in, so we disable it here.
--disable-rtree
> An R-Tree is a special index that is designed for doing range queries.
> R-Trees are most commonly used in geospatial systems...
https://www.sqlite.org/rtree.html
--disable-fts4 --disable-fts5
> FTS5 is an SQLite virtual table module that provides full-text
> search functionality to database applications.
DSQLITE_LIKE_DOESNT_MATCH_BLOBS
> simplifies the implementation of the LIKE optimization and allows
> queries that use the LIKE optimization to run faster.
DSQLITE_OMIT_DECLTYPE
> By omitting the (seldom-needed) ability to return the declared type of
> columns from the result set of query, prepared statements can be made
> to consume less memory.
DSQLITE_OMIT_PROGRESS_CALLBACK
> By omitting this interface, a single conditional is removed from the
> inner loop of the bytecode engine, helping SQL statements to run slightly
> faster.
DSQLITE_OMIT_AUTOINIT
> with the SQLITE_OMIT_AUTOINIT option, the automatic initialization is omitted.
> This helps many API calls to run a little faster
> it also means that the application must call sqlite3_initialize()
manually.