diff --git a/ci/test/00_setup_env.sh b/ci/test/00_setup_env.sh
index 2413cfca9f1..702e8818625 100755
--- a/ci/test/00_setup_env.sh
+++ b/ci/test/00_setup_env.sh
@@ -35,6 +35,10 @@ export USE_BUSY_BOX=${USE_BUSY_BOX:-false}
 export RUN_UNIT_TESTS=${RUN_UNIT_TESTS:-true}
 export RUN_FUNCTIONAL_TESTS=${RUN_FUNCTIONAL_TESTS:-true}
 export RUN_SECURITY_TESTS=${RUN_SECURITY_TESTS:-false}
+# By how much to scale the test_runner timeouts (option --timeout-factor).
+# This is needed because some ci machines have slow CPU or disk, so sanitizers
+# might be slow or a reindex might be waiting on disk IO.
+export TEST_RUNNER_TIMEOUT_FACTOR=${TEST_RUNNER_TIMEOUT_FACTOR:-4}
 export TEST_RUNNER_ENV=${TEST_RUNNER_ENV:-}
 export RUN_FUZZ_TESTS=${RUN_FUZZ_TESTS:-false}
 export EXPECTED_TESTS_DURATION_IN_SECONDS=${EXPECTED_TESTS_DURATION_IN_SECONDS:-1000}
diff --git a/ci/test/00_setup_env_native_asan.sh b/ci/test/00_setup_env_native_asan.sh
index 5995964f178..251ece79842 100644
--- a/ci/test/00_setup_env_native_asan.sh
+++ b/ci/test/00_setup_env_native_asan.sh
@@ -10,6 +10,5 @@ export CONTAINER_NAME=ci_native_asan
 export PACKAGES="clang llvm python3-zmq qtbase5-dev qttools5-dev-tools libevent-dev bsdmainutils libboost-system-dev libboost-filesystem-dev libboost-test-dev libboost-thread-dev libdb5.3++-dev libminiupnpc-dev libzmq3-dev libqrencode-dev"
 export DOCKER_NAME_TAG=ubuntu:20.04
 export NO_DEPENDS=1
-export TEST_RUNNER_EXTRA="--timeout-factor=4"  # Increase timeout because sanitizers slow down
 export GOAL="install"
 export BITCOIN_CONFIG="--enable-zmq --with-incompatible-bdb --with-gui=qt5 CPPFLAGS='-DARENA_DEBUG -DDEBUG_LOCKORDER' --with-sanitizers=address,integer,undefined CC=clang CXX=clang++ --with-boost-process"
diff --git a/ci/test/00_setup_env_native_tsan.sh b/ci/test/00_setup_env_native_tsan.sh
index fc184834257..b14a46562c5 100644
--- a/ci/test/00_setup_env_native_tsan.sh
+++ b/ci/test/00_setup_env_native_tsan.sh
@@ -10,6 +10,6 @@ export CONTAINER_NAME=ci_native_tsan
 export DOCKER_NAME_TAG=ubuntu:20.04
 export PACKAGES="clang llvm libc++abi-dev libc++-dev python3-zmq"
 export DEP_OPTS="CC=clang CXX='clang++ -stdlib=libc++'"
-export TEST_RUNNER_EXTRA="--exclude feature_block --timeout-factor=4"  # Increase timeout because sanitizers slow down. Low memory on Travis machines, exclude feature_block.
+export TEST_RUNNER_EXTRA="--exclude feature_block"  # Low memory on Travis machines, exclude feature_block.
 export GOAL="install"
 export BITCOIN_CONFIG="--enable-zmq --with-gui=no CPPFLAGS='-DARENA_DEBUG -DDEBUG_LOCKORDER' CXXFLAGS='-g' --with-sanitizers=thread CC=clang CXX='clang++ -stdlib=libc++' --with-boost-process"
diff --git a/ci/test/00_setup_env_native_valgrind.sh b/ci/test/00_setup_env_native_valgrind.sh
index 0041122f1e2..710d9e1011e 100644
--- a/ci/test/00_setup_env_native_valgrind.sh
+++ b/ci/test/00_setup_env_native_valgrind.sh
@@ -10,6 +10,6 @@ export CONTAINER_NAME=ci_native_valgrind
 export PACKAGES="valgrind clang llvm python3-zmq libevent-dev bsdmainutils libboost-system-dev libboost-filesystem-dev libboost-test-dev libboost-thread-dev libdb5.3++-dev libminiupnpc-dev libzmq3-dev"
 export USE_VALGRIND=1
 export NO_DEPENDS=1
-export TEST_RUNNER_EXTRA="--exclude rpc_bind --timeout-factor=4"  # Excluded for now, see https://github.com/bitcoin/bitcoin/issues/17765#issuecomment-602068547
+export TEST_RUNNER_EXTRA="--exclude rpc_bind"  # Excluded for now, see https://github.com/bitcoin/bitcoin/issues/17765#issuecomment-602068547
 export GOAL="install"
 export BITCOIN_CONFIG="--enable-zmq --with-incompatible-bdb --with-gui=no CC=clang CXX=clang++"  # TODO enable GUI
diff --git a/ci/test/06_script_b.sh b/ci/test/06_script_b.sh
index 96d44328b89..6c14a3dfbed 100755
--- a/ci/test/06_script_b.sh
+++ b/ci/test/06_script_b.sh
@@ -35,7 +35,7 @@ fi
 
 if [ "$RUN_FUNCTIONAL_TESTS" = "true" ]; then
   BEGIN_FOLD functional-tests
-  DOCKER_EXEC LD_LIBRARY_PATH=$DEPENDS_DIR/$HOST/lib ${TEST_RUNNER_ENV} test/functional/test_runner.py --ci $MAKEJOBS --tmpdirprefix "${BASE_SCRATCH_DIR}/test_runner/" --ansi --combinedlogslen=4000 ${TEST_RUNNER_EXTRA} --quiet --failfast
+  DOCKER_EXEC LD_LIBRARY_PATH=$DEPENDS_DIR/$HOST/lib ${TEST_RUNNER_ENV} test/functional/test_runner.py --ci $MAKEJOBS --tmpdirprefix "${BASE_SCRATCH_DIR}/test_runner/" --ansi --combinedlogslen=4000 --timeout-factor=${TEST_RUNNER_TIMEOUT_FACTOR} ${TEST_RUNNER_EXTRA} --quiet --failfast
   END_FOLD
 fi