diff --git a/depends/hosts/default.mk b/depends/hosts/default.mk
index ea60f025dec..7c76331ab4a 100644
--- a/depends/hosts/default.mk
+++ b/depends/hosts/default.mk
@@ -9,6 +9,7 @@ default_host_RANLIB = $(host_toolchain)ranlib
 default_host_STRIP = $(host_toolchain)strip
 default_host_LIBTOOL = $(host_toolchain)libtool
 default_host_NM = $(host_toolchain)nm
+default_host_OBJCOPY = $(host_toolchain)objcopy
 
 define add_host_tool_func
 ifneq ($(filter $(origin $1),undefined default),)
@@ -33,5 +34,5 @@ host_$1 = $$($(host_arch)_$(host_os)_$1)
 host_$(release_type)_$1 = $$($(host_arch)_$(host_os)_$(release_type)_$1)
 endef
 
-$(foreach tool,CC CXX AR RANLIB STRIP NM LIBTOOL OTOOL INSTALL_NAME_TOOL DSYMUTIL,$(eval $(call add_host_tool_func,$(tool))))
+$(foreach tool,CC CXX AR RANLIB STRIP LIBTOOL NM OBJCOPY OTOOL INSTALL_NAME_TOOL DSYMUTIL,$(eval $(call add_host_tool_func,$(tool))))
 $(foreach flags,CFLAGS CXXFLAGS CPPFLAGS LDFLAGS, $(eval $(call add_host_flags_func,$(flags))))
diff --git a/depends/packages/qt.mk b/depends/packages/qt.mk
index b45f8f5cf4c..e854843dab2 100644
--- a/depends/packages/qt.mk
+++ b/depends/packages/qt.mk
@@ -159,18 +159,10 @@ $(package)_config_opts_linux += -dbus-runtime
 ifneq ($(LTO),)
 $(package)_config_opts_linux += -ltcg
 endif
-$(package)_config_opts_arm_linux += -platform linux-g++ -xplatform bitcoin-linux-g++
-$(package)_config_opts_i686_linux  = -xplatform linux-g++-32
+$(package)_config_opts_linux += -platform linux-g++ -xplatform bitcoin-linux-g++
 ifneq (,$(findstring -stdlib=libc++,$($(1)_cxx)))
 $(package)_config_opts_x86_64_linux = -xplatform linux-clang-libc++
-else
-$(package)_config_opts_x86_64_linux = -xplatform linux-g++-64
 endif
-$(package)_config_opts_aarch64_linux = -xplatform linux-aarch64-gnu-g++
-$(package)_config_opts_powerpc64_linux = -platform linux-g++ -xplatform bitcoin-linux-g++
-$(package)_config_opts_powerpc64le_linux = -platform linux-g++ -xplatform bitcoin-linux-g++
-$(package)_config_opts_riscv64_linux = -platform linux-g++ -xplatform bitcoin-linux-g++
-$(package)_config_opts_s390x_linux = -platform linux-g++ -xplatform bitcoin-linux-g++
 
 $(package)_config_opts_mingw32 = -no-opengl
 $(package)_config_opts_mingw32 += -no-dbus
@@ -230,18 +222,11 @@ endef
 # 2. Create a macOS-Clang-Linux mkspec using our mac-qmake.conf.
 #
 # 3. After making a copy of the mkspec for the linux-arm-gnueabi host, named
-# bitcoin-linux-g++, replace instances of linux-arm-gnueabi with $(host). This
-# way we can generically support hosts like riscv64-linux-gnu, which Qt doesn't
-# ship a mkspec for. See it's usage in config_opts_* above.
+#    bitcoin-linux-g++, replace tool names with $($($(package)_type)_TOOL).
 #
 # 4. Put our C, CXX and LD FLAGS into gcc-base.conf. Only used for non-host builds.
 #
-# 5. Do similar for the win32-g++ mkspec.
-#
-# 6. In clang.conf, swap out clang & clang++, for our compiler + flags. See #17466.
-#
-# 7. Adjust a regex in toolchain.prf, to accommodate Guix's usage of
-# CROSS_LIBRARY_PATH. See #15277.
+# 5. In clang.conf, swap out clang & clang++, for our compiler + flags. See #17466.
 define $(package)_preprocess_cmds
   cp $($(package)_patch_dir)/qt.pro qt.pro && \
   cp $($(package)_patch_dir)/qttools_src.pro qttools/src/src.pro && \
@@ -261,7 +246,12 @@ define $(package)_preprocess_cmds
   cp -f qtbase/mkspecs/macx-clang/qplatformdefs.h qtbase/mkspecs/macx-clang-linux/ &&\
   cp -f $($(package)_patch_dir)/mac-qmake.conf qtbase/mkspecs/macx-clang-linux/qmake.conf && \
   cp -r qtbase/mkspecs/linux-arm-gnueabi-g++ qtbase/mkspecs/bitcoin-linux-g++ && \
-  sed -i.old "s/arm-linux-gnueabi-/$(host)-/g" qtbase/mkspecs/bitcoin-linux-g++/qmake.conf && \
+  sed -i.old "s|arm-linux-gnueabi-gcc|$($($(package)_type)_CC)|" qtbase/mkspecs/bitcoin-linux-g++/qmake.conf && \
+  sed -i.old "s|arm-linux-gnueabi-g++|$($($(package)_type)_CXX)|" qtbase/mkspecs/bitcoin-linux-g++/qmake.conf && \
+  sed -i.old "s|arm-linux-gnueabi-ar|$($($(package)_type)_AR)|" qtbase/mkspecs/bitcoin-linux-g++/qmake.conf && \
+  sed -i.old "s|arm-linux-gnueabi-objcopy|$($($(package)_type)_OBJCOPY)|" qtbase/mkspecs/bitcoin-linux-g++/qmake.conf && \
+  sed -i.old "s|arm-linux-gnueabi-nm|$($($(package)_type)_NM)|" qtbase/mkspecs/bitcoin-linux-g++/qmake.conf && \
+  sed -i.old "s|arm-linux-gnueabi-strip|$($($(package)_type)_STRIP)|" qtbase/mkspecs/bitcoin-linux-g++/qmake.conf && \
   echo "!host_build: QMAKE_CFLAGS     += $($(package)_cflags) $($(package)_cppflags)" >> qtbase/mkspecs/common/gcc-base.conf && \
   echo "!host_build: QMAKE_CXXFLAGS   += $($(package)_cxxflags) $($(package)_cppflags)" >> qtbase/mkspecs/common/gcc-base.conf && \
   echo "!host_build: QMAKE_LFLAGS     += $($(package)_ldflags)" >> qtbase/mkspecs/common/gcc-base.conf && \
diff --git a/depends/patches/qt/guix_cross_lib_path.patch b/depends/patches/qt/guix_cross_lib_path.patch
index 0c67743dc19..7911dc21d7d 100644
--- a/depends/patches/qt/guix_cross_lib_path.patch
+++ b/depends/patches/qt/guix_cross_lib_path.patch
@@ -4,7 +4,7 @@ See discussion in https://github.com/bitcoin/bitcoin/pull/15277.
 
 --- a/qtbase/mkspecs/features/toolchain.prf
 +++ b/qtbase/mkspecs/features/toolchain.prf
-@@ -231,8 +231,8 @@ isEmpty($${target_prefix}.INCDIRS) {
+@@ -236,8 +236,8 @@ isEmpty($${target_prefix}.INCDIRS) {
              add_libraries = false
              for (line, output) {
                  line ~= s/^[ \\t]*//  # remove leading spaces